Orange Juice Boosts Cognitive Function

October 6, 2016

Data published in the European Journal of Nutrition indicated that a 240 ml glass of the flavonoid-rich orange juice was associated with significantly improved scores for attention, executive function, and psychomotor speed in healthy middle-aged men without mild cognitive impairment six hours after consumption, compared with placebo.

Orange juice contains lutein and zeaxanthin, compounds believed to play an important role in preventing age-related macular degeneration (loss of vision) and cognitive impairment in the elderly.

Although orange juice has also been criticized in the past because of its high intrinsic sugar level, being associated with a higher risk of type 2 diabetes, recent intervention studies demonstrated the health benefits of long-term orange juice consumption, such as an increased total antioxidant status, lower total cholesterol levels, and the prevention of endotoxin increases after meals high in fat and carbohydrate.

Stick To Fresh

Pasteurized orange juice shows diminished carotenoid and vitamin C levels, by up to 20% so it’s important for consumers to consume freshly squeezed orange juice whenever possible.

Ever wonder why commercial orange juice–even the premium, not-from-concentrate, “100-percent pure” juice kind–tastes the same each time you buy it, but doesn’t taste exactly like a freshly peeled orange?

Turns out there’s a lot more to making juice than simply squeezing some citrus. As part of the mass-production process, big-name brands like Tropicana, Minute Maid, Simply Orange, and Florida’s Natural add artificial flavouring in order to make sure your juice tastes consistent from carton to carton–and to make sure it tastes like oranges.

Carotenoid bioaccessibility — how easily the body can absorb the nutrients also differs from person to person. The same bioaccessibility is also enhanced from 10% in oranges to almost 30% in freshly squeezed orange juice. Flavonoid bioaccessibility was boosted almost five-fold to 96.5%.

“It is important to acknowledge that orange juice consumption was not associated with a significant improvement on every individual cognitive test; this would not be expected given that the effects of nutritional interventions on cognitive performance are small and difficult to detect in healthy adults,” wrote the researchers.

“However, consistently higher means were observed following orange juice relative to the placebo in the vast majority of outcomes.”

Study Details

The researchers recruited 24 healthy men aged between 30 and 65 to participate in their randomized, double-blind, crossover study. The men were randomly assigned to consumer orange juice containing 272 mg of flavonoid or a calorie-matched placebo, with the interventions separated by two weeks.

A battery of tests revealed that, compared to placebo, the flavonoid-rich orange juice was associated with significantly better performance on tests of executive function and psychomotor speed.

Alertness was also reportedly improved following orange juice consumption.


Bioavailability data would suggest that the cognitive benefits observed after six hours are related to the flavanones hesperidin and narirutin, said the researchers.

“One plausible hypothesis is that flavonoid consumption may lead to acute cognitive benefits via increased [cerebral blood flow] as a result of enhanced endothelial function and increased bioavailability of nitric oxide,” they wrote. “Human studies show significantly increased [cerebral blood flow] several hours following cocoa flavanol consumption. These are supported by chronic studies which show increased activation in the right middle prefrontal cortex and the right superior parietal cortex following anthocyanin and flavanol-rich grape juice consumption.

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